PD 90780
Cat. No.：YN480435
CAS No. ：77422-99-2
规格
价格(RMB)
库存
| 产品名称: | PD 90780 |
| CAS No.: | 77422-99-2 |
| Chemical Name: | 7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxopyrazolo[5,1-b]quinazoline-2-carboxylic Acid; 7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxo-Pyrazolo[5,1-b]quinazoline-2-carboxylic Acid; |
| Synonyms: | |
| 分子量: | 362.34 |
| 分子式: | C₁₉H₁₄N₄O₄ |
| SMILES: | CN1C2=CC(C(O)=O)=NN2C(C3=CC(NC(C4=CC=CC=C4)=O)=CC=C13)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD 90780 是一种非肽类的神经生长因子NGF拮抗剂，与 NGF 上的 P75 受体结合，抑制 NGF 与神经营养素受体 p75 NTR (NGF-p75 NTR) 的相互作用，在 PC12 细胞和 PC12 nnr5 细胞中，抑制 NGF-p75 NTR 的IC50值分别为 23.1 µM 和 1.8 µM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Hefti, F. et al.: Trends Pharm. Sci., 27, 85 (2006)
Colquhoun, A. et al.: J. Pharm. Exp. Tter, 310, 505 (2004)
