Smurf1-IN-A01
Cat. No.：YN480436
CAS No. ：1007647-73-5
规格
价格(RMB)
库存
| 产品名称: | Smurf1-IN-A01 |
| CAS No.: | 1007647-73-5 |
| Chemical Name: | [4-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]-methanone |
| Synonyms: | A01 |
| 分子量: | 512.93 |
| 分子式: | C₂₂H₂₀ClF₃N₄O₃S |
| SMILES: | O=S(C1=CC(C(F)(F)F)=C(Cl)C=C1)(N2CCN(C(C3=CC=C(N4C(C)=CC=N4)C=C3)=O)CC2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Smurf1-IN-A01 (A01) 是一种泛素连接酶 Smad 泛素化调节因子-1(Smurf1)抑制剂，kd值为 3.664 nM，Smurf1-IN-A01 通过抑制 Smurf1 介导的 Smad1/5 降解来提高 BMP-2 的反应性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Cao, Y., Wang, C., Zhang, X., et al.Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradationSci. Rep.4,4965(2014)
