CINPA1
Cat. No.:YN480439
产品名称: | CINPA1 |
CAS No.: | 102636-74-8 |
Chemical Name: | [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-carbamic acid, ethyl ester |
Synonyms: | CINPA-1,CINPA 1 |
分子量: | 395.49 |
分子式: | C₂₃H₂₉N₃O₃ |
SMILES: | CCN(CC)CC(N1C2=CC(NC(OCC)=O)=CC=C2CCC3=C1C=CC=C3)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | CINPA1是一种不激活孕烷 X 受体 (PXR) 的,强效、特异性的组成型雄甾烷(CAR)抑制剂。CINPA1 能下调 CAR 介导的转录,IC50值为 ~70 nM。CINPA1 可以作为 CAR 功能研究的分子工具。 |
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Cherian, M.T., Lin, W., Wu, J., et al.CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptorMol. Pharmacol.87(5),878-889(2015)