Alendronate sodium hydrate
Cat. No.：YN480446
CAS No. ：121268-17-5
规格
价格(RMB)
库存
| 产品名称: | Alendronate sodium hydrate |
| CAS No.: | 121268-17-5 |
| Chemical Name: | P,P'-(4-amino-1-hydroxybutylidene)bis-phosphonic acid, monosodium salt trihydrate (1:1:3) |
| Synonyms: | 阿仑膦酸钠; Alendronate; MK 217; G-704650 Adronat |
| 分子量: | 325.12 |
| 分子式: | C₄H₁₈NNaO₁₀P₂ |
| SMILES: | OP(C(O)(CCCN)P(O)(O[Na])=O)(O)=O.[3H2O] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Alendronate sodium hydrate 是一种 farnesyl diphosphate synthase 抑制剂，IC50值为 460 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Dunford, J.E., Thompson, K., Coxon, F.P., et al.Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonatesJ. Pharmacol. Exp. Ther.296(2),235-242(2001)
Sahni, M., Guenther, H.L., Fleisch, H., et al.Bisphosphonates act on rat bone resorption through the mediation of osteoblastsJ. Clin. Invest.91(5),2004-2011(1993)
Ye, Y., Lv, X., Wang, M.-h., et al.Alendronate prevents angiotensin II-induced collagen I production through geranylgeranylation-dependent RhoA/Rho kinase activation in cardiac fibroblastsJ. Pharmacol. Sci.129(4),205-209(2015)
Azuma, Y., Oue, Y., Kanatani, H., et al.Effects of continuous alendronate treatment on bone mass and mechanical properties in ovariectomized rats: Comparison with pamidronate and etidronate in growing ratsJ. Pharmacol. Exp. Ther.286(1),128-135(1998)
