DIM-C-pPhOCH3
Cat. No.：YN480464
CAS No. ：33985-68-1
规格
价格(RMB)
库存
| 产品名称: | DIM-C-pPhOCH3 |
| CAS No.: | 33985-68-1 |
| Chemical Name: | 3,3'-[(4-methoxyphenyl)methylene]bis-1H-indole |
| Synonyms: | C-DIM5 |
| 分子量: | 352.43 |
| 分子式: | C₂₄H₂₀N₂O |
| SMILES: | COC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DIM-C-pPhOCH3是一种Nur77激动剂。Nur77 是一种孤儿核受体。 |
| IC50和靶点: | |
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Chintharlapalli, S., Burghardt, R., Papineni, S., et al.Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathwaysJ. Biol. Chem.280(26),24903-24914(2005)
Yoon, K., Lee, S.O., Cho, S.D., et al.Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumorsCarcinogenesis32(6),836-842(2011)
Popichak, K.A., Hammond, S.L., Moreno, J.A., et al.Compensatory expression of Nur77 and Nurr1 regulates NF-κB-dependent inflammatory signaling in astrocytesMol. Pharmacol.94(4),1174-1186(2018)
De Miranda, B.R., Miller, J.A., Hansen, R.J., et al.Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's diseaseJ. Pharmacol. Exp. Ther.345(1),125-138(2013)
