SHIN1
Cat. No.:YN480501
产品名称: | SHIN1 |
CAS No.: | 2146095-85-2 |
Chemical Name: | 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1′-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-pyrano[2,3-c]pyrazole-5-carbonitrile |
Synonyms: | RZ-2994 |
分子量: | 400.47 |
分子式: | C₂₄H₂₄N₄O₂ |
SMILES: | OCC1=CC(C2=CC=CC=C2)=CC(C3(C(C(C)=NN4)=C4OC(N)=C3C#N)C(C)C)=C1 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | SHIN1 (RZ-2994) 是人丝氨酸羟甲基转移酶1和2 (SHMT1/2) 抑制剂,体外实验中的其IC50值分别为5和13 nM。 |
IC50和靶点: | |
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Solvent & Solubility: |
He, L., Endress, J., Cho, S., et al.Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cellsSci. Adv.8(20),eabm8786(2022)