WNK-IN-11
Cat. No.:YN480506
产品名称: | WNK-IN-11 |
CAS No.: | 2123489-30-3 |
Chemical Name: | [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]-methanone |
Synonyms: | Allosteric WNK Kinase Inhibitor |
分子量: | 462.40 |
分子式: | C₂₁H₂₁Cl₂N₅OS |
SMILES: | O=C(C1=CC(C2=CSC(NC)=N2)=NC=C1Cl)N3CCN(CC4=CC=C(Cl)C=C4)CC3 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | WNK-IN-11 是(WNK)激酶的变构抑制剂,其对 WNK1 的IC50值为 4 nM。 |
IC50和靶点: | |
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Yamada, K., Levell, J., Yoon, T.K., et al.Optimization of allosteric with-no-lysine (WNK) kinase inhibitors and efficacy in rodent hypertension modelsJ. Med. Chem.60(16),7099-7107(2017)