TAO Kinase inhibitor 1
Cat. No.：YN480520
CAS No. ：850467-66-2
规格
价格(RMB)
库存
| 产品名称: | TAO Kinase inhibitor 1 |
| CAS No.: | 850467-66-2 |
| Chemical Name: | N-[2-oxo-2-[(1,2,3,4-tetrahydro-1-naphthalenyl)amino]ethyl]-[1,1'-biphenyl]-4-carboxamide |
| Synonyms: | Compound 43, TAO Kinase inhibitor 1, TAOK inhibitor 43, |
| 分子量: | 384.47 |
| 分子式: | C₂₅H₂₄N₂O₂ |
| SMILES: | O=C(CNC(C1=CC=C(C2=CC=CC=C2)C=C1)=O)NC(CCC3)C4=C3C=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TAO Kinase inhibitor 1 (compound 43) 是一种选择性的、ATP 竞争性的thousand-and-one amino acid kinases (TAOK)抑制剂，针对 TAOK1 和 TAOK2 的IC50s 分别为 11 nM 和 15 nM。TAO Kinase inhibitor 1 延迟有丝分裂以及诱导有丝分裂细胞死亡。 |
| IC50和靶点: | |
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Koo, C.Y., Giacomini, C., Reyes-Corral, M., et al.Targeting TAO kinases using a new inhibitor compound delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells.Mol. Cancer Ther.16(11),2410-2421(2017)
Giacomini, C., Koo, C.Y., Yankova, N., et al.A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathiesActa. Neuropathol. Commun.6(1),37(2018)
