N1-Methylpseudouridine
Cat. No.：YN480540
CAS No. ：13860-38-3
规格
价格(RMB)
库存
| 产品名称: | N1-Methylpseudouridine |
| CAS No.: | 13860-38-3 |
| Chemical Name: | 1-methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione |
| Synonyms: | 1-Methylpseudouridine |
| 分子量: | 258.23 |
| 分子式: | C₁₀H₁₄N₂O₆ |
| SMILES: | O=C(N1)N(C)C=C([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | N1-methyl-pseudouridine (1-Methylpseudouridine) 是一种甲基假尿苷，翻译性能优于 5 mC 和 5 mC/N1-methyl-pseudouridine。通过增加核糖体密度，mRNA 中的 N1-methyl-pseudouridine 以 eIF2α 依赖性和独立机制增强翻译。 |
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Argoudelis, A.D., and Mizsak, S.A.1-Methylpseudouridine, a metabolite of Streptomyces platensisJ. Antibiot. (Tokyo)29(8),818-823(1976)
Kierzek, E., Malgowska, M., Lisowiec, J., et al.The contribution of pseudouridine to stabilities and structure of RNAsNucleic Acids Res.42(5),3492-3501(2014)
Andries, O., Mc Cafferty, S., De Smedt, S.C., et al.N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and miceJ. Control. Release217,337-344(2015)
Parr, C.J., Wada, S., Kotake, K., et al.N1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cellsNucleic Acids Res.48(6),e35(2020)
