ML-290
Cat. No.：YN480543
CAS No. ：1482500-76-4
规格
价格(RMB)
库存
| 产品名称: | ML-290 |
| CAS No.: | 1482500-76-4 |
| Chemical Name: | 2-[[2-(1-methylethoxy)benzoyl]amino]-N-[3-[(trifluoromethyl)sulfonyl]phenyl]-benzamide |
| Synonyms: | |
| 分子量: | 506.49 |
| 分子式: | C₂₄H₂₁F₃N₂O₅S |
| SMILES: | O=C(NC1=CC(S(=O)(C(F)(F)F)=O)=CC=C1)C2=C(NC(C3=CC=CC=C3OC(C)C)=O)C=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML-290 是一种首创、有效的松弛素/胰岛素样肽受体 (RXFP1) 激动剂，为抗纤维化基因激活剂，EC50值为 94 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Xiao, J., Chen, C.Z., Huang, Z., et al.Discovery, optimization, and biological activity of the first potent and selective small-molecule agonist series of human relaxin receptor 1 (RXFP1)Probe Reports from the NIH Molecular Libraries Program,(2012)
Huang, Z., Myhr, C., Bathgate, R.A.D., et al.Activation of relaxin family receptor 1 from different mammalian species by relaxin peptide and small-molecule agonist ML290Front. Endocrinol. (Lausanne)6,128(2015)
Kaftanovskaya, E.M., Ng, H.H., Soula, M., et al.Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosisFASEB J.33(11),12435-12446(2019)
