V-9302
Cat. No.：YN480552
CAS No. ：1855871-76-9
规格
价格(RMB)
库存
| 产品名称: | V-9302 |
| CAS No.: | 1855871-76-9 |
| Chemical Name: | (2S)-2-amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]-butanoic acid |
| Synonyms: | V-9302; V9302; V 9302 |
| 分子量: | 538.68 |
| 分子式: | C₃₄H₃₈N₂O₄ |
| SMILES: | O=C(O)[C@@H](N)CCN(CC1=CC=CC=C1OCC2=CC=CC(C)=C2)CC3=CC=CC=C3OCC4=CC=CC(C)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | V-9302 是跨膜谷氨酰胺通量的竞争性拮抗剂。V-9302 有效选择性的靶向氨基酸转运体ASCT2 (SLC1A5)。V-9302 抑制了 HEK-293 细胞中由 ASCT2 介导的谷氨酰胺摄取 (IC50=9.6 μM)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Schulte, M.L., Khodadadi, A.B., Cuthbertson, M.L., et al.2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transportBioorg. Med. Chem. Lett.26(3),1044-1047(2016)
Schulte, M.L., Fu, A., Zhao, P., et al.Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical modelsNat. Med.24(2),194-202(2018)
