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N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride

Cat. No.:YN480555

  • CAS No. :4272-74-6

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    • 产品名称: N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
      CAS No.: 4272-74-6
      Chemical Name: N-[5-amino-1-(2-chloroacetyl)pentyl]-4-methyl-benzenesulfonamide, monohydrochloride
      Synonyms:N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride
      分子量:369.31
      分子式:C₁₄H₂₂Cl₂N₂O₃S
      SMILES:O=S(C1=CC=C(C)C=C1)(N[C@H](C(CCl)=O)CCCCN)=O.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK) 是一种胰蛋白酶样蛋白酶抑制剂,使 HeLa 细胞对 Fas 介导的细胞死亡敏感。
      IC50和靶点:
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    • Griscavage, J.M., Wilk, S., and Ignarro, L.J.Serine and cysteine proteinase inhibitors prevent nitric oxide production by activated macrophages by interfering with transcription of the inducible NO synthase geneBiochem. Biophys. Res. Commun.215(2),721-729(1995)

      Urban, M.K., Franklin, S.G., and Zweidler, A.Isolation and characterization of the histone variants in chicken erythrocytesBiochemistry18(18),3952-3960(1979)

      Józwiak, J., Komar, A., Jankowska, E., et al.Inhibition of Clostridium histolyticum supernatant cytotoxic activity by protease inhibitorsEnzyme Microb. Technol.39(1),28-31(2006)

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