Inflachromene
Cat. No.：YN480594
CAS No. ：908568-01-4
规格
价格(RMB)
库存
| 产品名称: | Inflachromene |
| CAS No.: | 908568-01-4 |
| Chemical Name: | 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-[1]benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione |
| Synonyms: | ICM |
| 分子量: | 377.39 |
| 分子式: | C₂₁H₁₉N₃O₄ |
| SMILES: | O=C1N(C2=CC=CC=C2)C(N3CC=C(C(C)(C)OC4=CC(O)=CC=C45)C5N31)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Inflachromene 是一种小胶质细胞抑制剂，可与HMGB1和HMGB2结合并发挥抗炎作用。Inflachromene 有效下调HMGB的促炎功能并减少神经元损伤。Inflachromene 可用于神经炎性疾病的研究。 |
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Lee, S., Nam, Y., Koo, J.Y., et al.A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammationNat. Chem. Biol.10(12),1055-1060(2014)
Cho, W., Koo, J.Y., Park, Y., et al.Treatment of sepsis pathogenesis with high mobility group box protein 1-regulating anti-inflammatory agentsJ. Med. Chem.60(1),170-179(2017)
