AKR1C1-IN-1
Cat. No.：YN480602
CAS No. ：4906-68-7
规格
价格(RMB)
库存
| 产品名称: | AKR1C1-IN-1 |
| CAS No.: | 4906-68-7 |
| Chemical Name: | 5-bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid |
| Synonyms: | |
| 分子量: | 293.11 |
| 分子式: | C₁₃H₉BrO₃ |
| SMILES: | O=C(C1=CC(C2=CC=CC=C2)=CC(Br)=C1O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AKR1C1-IN-1 是一种高效、选择性的AKR1C1抑制剂，其Ki值为 4 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Zhang, Y., Dufort, I., Rheault, P., et al.Characterization of a human 20α-hydroxysteroid dehydrogenaseJ. Mol. Endocrinol.25(2),221-228(2000)
Lewis, M.J., Wiebe, J.P., and Heathcote, J.G.Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinomaBMC Cancer4,27(2004)
Wang, H.W., Lin, C.P., Chiu, J.H., et al.Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysinInt. J. Cancer120(9),2019-2027(2007)
Belelli, D., Herd, M.B., Mitchell, E.A., et al.Neuroactive steroids and inhibitory neurotransmission: Mechanisms of action and physiological relevanceNeuroscience138(3),821-829(2006)
Usami, N., Yamamoto, T., Shintani, S., et al.Substrate specificity of human 3(20)α-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepinesBiol. Pharm. Bull.25(4),441-445(2002)
El-Kabbani, O., Scammells, P.J., Gosling, J., et al.Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20α-hydroxysteroid dehydrogenase (AKR1C1)J. Med. Chem.52(10),3259-3264(2009)
