Pyridoxal isonicotinoyl hydrazone
Cat. No.：YN480628
CAS No. ：737-86-0
规格
价格(RMB)
库存
| 产品名称: | Pyridoxal isonicotinoyl hydrazone |
| CAS No.: | 737-86-0 |
| Chemical Name: | 4-pyridinecarboxylic acid, 2-[[3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl]methylene]hydrazide |
| Synonyms: | PIH |
| 分子量: | 286.29 |
| 分子式: | C₁₄H₁₄N₄O₃ |
| SMILES: | CC1=NC=C(C(/C=N/NC(C2=CC=NC=C2)=O)=C1O)CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pyridoxal isonicotinoyl hydrazine (PIH) 是一种亲脂的三价铁螯合剂，显示出高铁螯合作用。 |
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Ponka, P., Borova, J., Neuwirt, J., et al.Mobilization of iron from reticulocytes. Identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agentFEBS Lett.97(2),317-321(1979)
Richardson, D.R., and Ponka, P.Pyridoxal isonicotinoyl hydrazone and its analogs: Potential orally effective iron-chelating agents for the treatment of iron overload diseaseJ. Lab. Clin. Med.131(4),306-315(1998)
Merlot, A.M., Pantarat, N., Lovejoy, D.B., et al.Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancerMol. Pharmacol.78(4),675-684(2010)
Richardson, D.R.Cytotoxic analogs of the iron(III) chelator pyridoxal isonicotinoyl hydrazone: Effects of complexation with copper(II), gallium(III), and iron (III) on their antiproliferative activitiesAntimicrob. Agents Chemother.41(9),2061-2063(1997)
Gao, J., and Richardson, D.R.The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progressionBlood98(3),842-850(2001)
