ADAMTS-5 Inhibitor
Cat. No.：YN480632
CAS No. ：929634-33-3
规格
价格(RMB)
库存
| 产品名称: | ADAMTS-5 Inhibitor |
| CAS No.: | 929634-33-3 |
| Chemical Name: | 5-[[5-[[(4-chlorophenyl)methyl]thio]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methylene]-2-thioxo-4-thiazolidinone |
| Synonyms: | |
| 分子量: | 449.92 |
| 分子式: | C₁₆H₁₁ClF₃N₃OS₃ |
| SMILES: | O=C1NC(S/C1=C\C2=C(SCC3=CC=C(Cl)C=C3)N(C)N=C2C(F)(F)F)=S |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ADAMTS-5 Inhibitor 是一种有效的ADAMTS-5 (aggrecanase-2)抑制剂，IC50为 1.1 μM。ADAMTS-5 Inhibitor 的功能选择性比 ADAMTS-4 (aggrecanase-2) 高出 40 倍以上。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bondeson, J., Wainwright, S., Hughes, C., et al.The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: A reviewClin. Exp. Rheumatol.26(1),139-145(2008)
Lemarchant, S., Pruvost, M., Montaner, J., et al.ADAMTS proteoglycanases in the physiological and pathological central nervous systemJ. Neuroinflammation10,1-8(2013)
Bursavich, M.G., Gilbert, A.M., Lombardi, S., et al.Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2)Bioorg. Med. Chem. Lett.17(5),1185-1188(2007)
Gilbert, A.M., Bursavich, M.G., Lombardi, S., et al.5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5Bioorg. Med. Chem. Lett.17(5),1189-1192(2007)
