SPR inhibitor 3
Cat. No.：YN480641
CAS No. ：1292285-54-1
规格
价格(RMB)
库存
| 产品名称: | SPR inhibitor 3 |
| CAS No.: | 1292285-54-1 |
| Chemical Name: | N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxy-acetamide |
| Synonyms: | SPRi3 |
| 分子量: | 262.30 |
| 分子式: | C₁₄H₁₈N₂O₃ |
| SMILES: | O=C(NCCC1=C(C)NC2=C1C=C(O)C=C2)COC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SPR inhibitor 3 (SPRi3) 是一种有效的 sepiapertin 还原酶(SPR)抑制剂。SPR inhibitor 3 (SPRi3) 在非细胞体系中显示出与人 SPR 的高结合亲和力 (IC50=74 nM)，在细胞检测中有效降低生物喋呤水平 (IC50=5.2 μM)。SPR inhibitor 3 (SPRi3) 通过降低 BH4 水平减少神经性和炎症性疼痛。 |
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Meyer, J.T., Sparling, B.A., McCarty, W.J., et al.Pharmacological assessment of sepiapterin reductase inhibition on tactile response in the ratJ. Pharmacol. Exp. Ther.371(2),476-486(2019)
Latremoliere, A., Latini, A., Andrews, N., et al.Reduction of neuropathic and inflammatory pain through inhibition of the tetrahydrobiopterin pathwayNeuron.86(6),1393-1406(2015)
Cronin, S.J.F., Seehus, C., Weidinger, A., et al.The metabolite BH4 controls T cell proliferation in autoimmunity and cancerNature563(7732),564-568(2018)
