BCATc Inhibitor 2
Cat. No.：YN480649
CAS No. ：406191-34-2
规格
价格(RMB)
库存
| 产品名称: | BCATc Inhibitor 2 |
| CAS No.: | 406191-34-2 |
| Chemical Name: | 5-chloro-2-benzofurancarboxylic acid 2-[[2-(trifluoromethyl)phenyl]sulfonyl]hydrazide |
| Synonyms: | |
| 分子量: | 418.77 |
| 分子式: | C₁₆H₁₀ClF₃N₂O₄S |
| SMILES: | ClC1=CC=C2C(C=C(O2)C(NNS(C3=C(C=CC=C3)C(F)(F)F)(=O)=O)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BCATc Inhibitor 2 是一种选择性的分支链氨基转移酶 (BCAT) 抑制剂，可用于神经退行性疾病的研究。对 rBCATc，hBCATc 和 rBCATm 的 IC50分别为 0.2 μM，0.8 μM 和 3.0 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Brosnan, J.T., and Brosnan, M.E.Branched-chain amino acids: Enzyme and substrate regulationJ. Nutr.136(1),207S-211S(2006)
Goto, M., Miyahara, I., Hayashi, H., et al.Crystal structures of branched-chain amino acid aminotransferase complexed with glutamate and glutarate: True reaction intermediate and double substrate recognition of the enzymeBiochem.42(13),3725-3733(2003)
Bora, K., Hu, L.Y., Kesten, S.R., et al.Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseasesPCT/US01/25892,(2002)
Hu, L.Y., Boxer, P.A., Kesten, S.R., et al.The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseasesBioorg. Med. Chem. Lett.16(9),2337-2340(2006)
Caballero, J., Vergara-Jaque, A., Fernández, M., et al.Docking and quantitative structure-activity relationship studies for sulfonyl hydrazides as inhibitors of cytosolic human branched-chain amino acid aminotransferaseMol. Divers.13(4),493-500(2009)
