LP-935509
Cat. No.：YN480677
CAS No. ：1454555-29-3
规格
价格(RMB)
库存
| 产品名称: | LP-935509 |
| CAS No.: | 1454555-29-3 |
| Chemical Name: | 4-[3-(2-methoxy-3-pyridinyl)pyrazolo[1,5-a]pyrimidin-5-yl]-1-piperazinecarboxylic acid, 1-methylethyl ester |
| Synonyms: | |
| 分子量: | 396.44 |
| 分子式: | C₂₀H₂₄N₆O₃ |
| SMILES: | O=C(N1CCN(C2=NC3=C(C4=CC=CN=C4OC)C=NN3C=C2)CC1)OC(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LP-935509 是选择性和具有脑渗透的一种小分子衔接蛋白-2 相关激酶1 (AAK1) ATP 竞争性抑制剂，IC50和Ki分别为 3.3 nM 和 0.9 nM。LP-935509 也是 BIKE 的有效抑制剂 (IC50=14 nM) 和中度的 GAK 抑制剂 (IC50=320 nM)。LP-935509 可逆转 SNL 手术后的疼痛。 |
| IC50和靶点: | |
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Kostich, W., Hamman, B.D., Li, Y.-W., et al.Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic painJ. Pharmacol. Exp. Ther.358(3),371-386(2016)
Liu, Q., Bautista-Gomez, J., Higgins, D.A., et al.Dysregulation ofthe AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegenerationSci. Signal.14(693),eabg3555(2021)
