HJC0197
Cat. No.：YN480682
CAS No. ：1383539-73-8
规格
价格(RMB)
库存
| 产品名称: | HJC0197 |
| CAS No.: | 1383539-73-8 |
| Chemical Name: | 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-5-pyrimidinecarbonitrile |
| Synonyms: | HJC0197;HJC-0197;HJC 0197 |
| 分子量: | 339.45 |
| 分子式: | C₁₉H₂₁N₃OS |
| SMILES: | N#CC1=C(C2CCCC2)N=C(SCC3=CC(C)=CC=C3C)NC1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HJC0197 是一种有效的Epac1(cAMP 1 直接激活的交换蛋白) 和Epac2(对 Epac2 的IC50=5.9 μM) 拮抗剂。HJC0197 选择性阻断 cAMP 诱导的 Epac 活化。HJC0197 在等浓度 cAMP 存在下抑制 Epac1 介导的 Rap1-GDP 交换活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Chen, H., Tsalkova, T., Mei, F.C., et al.5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMPBioorg. Med. Chem. Lett.22(12),4038-4043(2012)
Juhász, T., Matta, C., Somogyi, C., et al.Mechanical loading stimulates chondrogenesis via the PKA/CREB-Sox9 and PP2A pathways in chicken micromass culturesCell Signal.26,468-482(2014)
