α-Hydroxytamoxifen
Cat. No.：YN480685
CAS No. ：97151-02-5
规格
价格(RMB)
库存
| 产品名称: | α-Hydroxytamoxifen |
| CAS No.: | 97151-02-5 |
| Chemical Name: | (βE)-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]-α-methyl-benzeneethanol |
| Synonyms: | (E)-α-Hydroxy tamoxifen; α-OHTAM |
| 分子量: | 387.51 |
| 分子式: | C₂₆H₂₉NO₂ |
| SMILES: | CC(/C(C1=CC=CC=C1)=C(C2=CC=C(C=C2)OCCN(C)C)\C3=CC=CC=C3)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | α-Hydroxytamoxifen 是 tamoxifen 的代谢物，在没有代谢酶的条件下可与 DNA 相互反应，并导致 DNA 加合物的形成。 |
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Boocock, D.J., Maggs, J.L., White, I.N.H., et al.α-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: Identification and quantification in vivo and in vitroCarcinogenesis20(1),153-160(1999)
Mugundu, G.M., Sallans, L., Guo, Y., et al.Assessment of the impact of CYP3A polymorphisms on the formation of α-hydroxytamoxifen and N-desmethyltamoxifen in human liver microsomesDrug Metab. Dispos.40(2),389-396(2012)
White, I.N.H., Carthew, P., Davies, R., et al.Short-term dosing of α-hydroxytamoxifen results in DNA damage but does not lead to liver tumours in female Wistar/Han ratsCarcinogenesis22(4),553-557(2001)
Yadollahi-Farsani, M., Davies, D.S., and Boobis, A.R.The mutational signature of α-hydroxytamoxifen at Hprt locus in Chinese hamster cellsCarcinogenesis23(11),1947-1952(2002)
Shibutani, S., Dasaradhi, L., Terashima, I., et al.α-Hydroxytamoxifen is a substrate of hydroxysteroid (alcohol) sulfotransferase, resulting in tamoxifen DNA adductsCancer Res.58(4),647-653(1998)
Kim, S.Y., Laxmi, Y.R.S., Suzuki, N., et al.Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of α-hydroxytamoxifen in rat and human liversDrug Metab. Dispos.33(11),1673-1678(2005)
