PhIP
Cat. No.：YN480692
CAS No. ：105650-23-5
规格
价格(RMB)
库存
| 产品名称: | PhIP |
| CAS No.: | 105650-23-5 |
| Chemical Name: | 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine |
| Synonyms: | |
| 分子量: | 224.26 |
| 分子式: | C₁₃H₁₂N₄ |
| SMILES: | NC1=NC2=NC=C(C=C2N1C)C3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PhIP 是在熟肉中形成的杂环芳香胺 (HAA)，是一种可能的致癌物。具有 DNA 破坏性和诱变性。 PhIP 还具有雌激素活性，可能有助于其组织特异性致癌性。 |
| IC50和靶点: | |
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Choudhary, S., Sood, S., Donnell, R.L., et al.Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridineCarcinogenesis33(4),876-885(2012)
Shirai, T., Sano, M., Tamano, S., et al.The prostate: A target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foodsCancer Res.57(2),195-198(1997)
Wang, H., Zhou, H., Liu, A., et al.Genetic analysis of colon tumors induced by a dietary carcinogen PhIP in CYP1A humanized mice: Identification of mutation of β-catenin/Ctnnb1 as the driver gene for the carcinogenesisMol. Carcinog.54(11),1264-1274(2015)
