BRM/BRG1 ATP Inhibitor-1
Cat. No.：YN480703
CAS No. ：2270879-17-7
规格
价格(RMB)
库存
| 产品名称: | BRM/BRG1 ATP Inhibitor-1 |
| CAS No.: | 2270879-17-7 |
| Chemical Name: | N-[3-(difluoromethyl)-5-isothiazolyl]-N′-[2-fluoro-5-(hydroxymethyl)-4-pyridinyl]-urea |
| Synonyms: | |
| 分子量: | 318.27 |
| 分子式: | C₁₁H₉F₃N₄O₂S |
| SMILES: | FC1=CC(NC(NC2=CC(C(F)F)=NS2)=O)=C(CO)C=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BRM/BRG1 ATP Inhibitor-1 是一种变构 brahma 同系物(BRM)/SMARCA2(SWI/SNF 相关的染色质亚家族成员 2 的基质相关肌动蛋白依赖调节因子) 和 brahma 相关基因 1(BRG1)/SMARCA4三磷酸腺苷酶活性双抑制剂，IC50值均低于 0.005 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Papillon, J.P.N., Nakajima, K., Adair, C.D., et al.Discovery of orally active inhibitors of brahma homolog (BRM)/SMARCA2 ATPase activity for the treatment of brahma related gene 1 (BRG1)/SMARCA4-mutant cancersJ. Med. Chem.61(22),10155-10172(2018)
