Neridronate
Cat. No.：YN480708
CAS No. ：79778-41-9
规格
价格(RMB)
库存
| 产品名称: | Neridronate |
| CAS No.: | 79778-41-9 |
| Chemical Name: | P,P′-(6-amino-1-hydroxyhexylidene)bis-phosphonic acid |
| Synonyms: | 奈立膦酸 |
| 分子量: | 277.15 |
| 分子式: | C₆H₁₇NO₇P₂ |
| SMILES: | OC(P(O)(O)=O)(CCCCCN)P(O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Neridronate 是一种氨基二膦酸盐，有潜力用于成骨不全症 (OI) 和佩吉特骨病 (PDB)。Neridronate 对其他骨骼疾病也有效，如骨质疏松症，骨痛退化症，恶性高钙血症和骨转移病变。 |
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Dunford, J.E., Kwaasi, A.A., Rogers, M.J., et al.Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: Time-dependent inhibition of human farnesyl pyrophosphate synthaseJ. Med. Chem.51(7),2187-2195(2008)
Nicolin, V., Bareggi, R., Baldini, G., et al.Effects of neridronic acid on osteoclasts derived by physiological dual-cell culturesActa Histochem.109(5),397-402(2007)
Ribatti, D., Nico, B., Mangieri, D., et al.Neridronate inhibits angiogenesis in vitro and in vivoClin. Rheumatol.26(7),1094-1098(2007)
Schenk, R., Eggli, P., Fleisch, H., et al.Quantitative morphometric evaluation of the inhibitory activity of new aminobisphosphonates on bone resorption in the ratCalcif. Tissue Int.38(6),342-349(1986)
