XEN445
Cat. No.:YN480757
产品名称: | XEN445 |
CAS No.: | 1515856-92-4 |
Chemical Name: | 2-[(3S)-3-(2-pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)-benzoic acid |
Synonyms: | XEN-445,2-[(3S)-3-(2-吡啶基甲氧基)-1-吡咯烷基]-5-(三氟甲基)苯甲酸,XEN 445 |
分子量: | 366.33 |
分子式: | C₁₈H₁₇F₃N₂O₃ |
SMILES: | O=C(O)C1=CC(C(F)(F)F)=CC=C1N2C[C@@H](OCC3=NC=CC=C3)CC2 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | XEN445是内皮脂肪酶(EL)抑制剂,IC50为0.237 uM,具有很好的ADME和PK活性,能提高小鼠血浆中高密度脂蛋白胆固醇浓度。 |
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Sun, S., Dean, R., Jia, Q., et al.Discovery of XEN445: A potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in miceBioorg. Med. Chem.21(24),7724-7734(2013)