Ro 61-8048
Cat. No.：YN480781
CAS No. ：199666-03-0
规格
价格(RMB)
库存
| 产品名称: | Ro 61-8048 |
| CAS No.: | 199666-03-0 |
| Chemical Name: | 3,4-dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide |
| Synonyms: | |
| 分子量: | 421.45 |
| 分子式: | C₁₇H₁₅N₃O₆S₂ |
| SMILES: | O=S(C1=CC=C(OC)C(OC)=C1)(NC2=NC(C3=CC=CC([N+]([O-])=O)=C3)=CS2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ro 61-8048 是口服有效的、选择性的犬尿氨酸 3-羟化酶 (kynurenine 3-hydroxylase) 的抑制剂，其IC50值为 37 nM。Ro 61-8048 引起细胞喹啉酸浓度的显著增加。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Röver, S., Cesura, A.M., Huguenin, P., et al.Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylaseJ. Med. Chem.40(26),4378-4385(1997)
Carpenedo, R., Meli, E., Peruginelli, F., et al.Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice culturesJ. Neurochem.82(6),1465-1471(2002)
Hamann, M., Sander, S.E., and Richter, A.Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dtsz mutantEur. J. Pharmacol.586(1-3),156-159(2008)
