KPT-6566
Cat. No.：YN480789
CAS No. ：881487-77-0
规格
价格(RMB)
库存
| 产品名称: | KPT-6566 |
| CAS No.: | 881487-77-0 |
| Chemical Name: | 2-[[4-[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]imino]-1,4-dihydro-1-oxo-2-naphthalenyl]thio]-acetic acid |
| Synonyms: | 2-[[4-[[[4-(叔丁基)苯基]磺酰基]亚氨基]-1-氧代-1,4-二氢-2-萘基]硫基]乙酸 |
| 分子量: | 443.54 |
| 分子式: | C₂₂H₂₁NO₅S₂ |
| SMILES: | O=C(O)CSC(C1=O)=C/C(C2=C1C=CC=C2)=N\S(=O)(C3=CC=C(C(C)(C)C)C=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KPT-6566 是一种有效、选择性、共价结合的脯氨酰异构酶PIN1抑制剂，与 PIN1 的催化位点共价结合，抑制并降解PIN1。KPT-6566 对PIN1 PPIase结构域的IC50和Ki值分别为 640 nM 和 625.2 nM。KPT-6566 具有抗癌作用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Campaner, E., Rustighi, A., Zannini, A., et al.A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of actionNat. Commun.8(1),15772(2017)
