Zotarolimus
Cat. No.：YN480801
CAS No. ：221877-54-9
规格
价格(RMB)
库存
| 产品名称: | Zotarolimus |
| CAS No.: | 221877-54-9 |
| Chemical Name: | (42S)-42-deoxy-42-(1H-tetrazol-1-yl)-rapamycin |
| Synonyms: | 佐他莫司; ABT-578; A 179578 |
| 分子量: | 966.21 |
| 分子式: | C₅₂H₇₉N₅O₁₂ |
| SMILES: | CO[C@H]1[C@@H](N2C=NN=N2)CC[C@@H](C[C@H]([C@@](CC([C@@H](/C=C([C@H]([C@H](C([C@@H](C[C@@H]3C)C)=O)OC)O)\C)C)=O)([H])OC([C@@](CCCC4)([H])N4C(C([C@](O[C@]5([H])C[C@@H](/C(C)=C/C=C/C=C/3)OC)([C@@H](CC5)C)O)=O)=O)=O)C)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Zotarolimus 是雷帕霉素 (HY-10219) 的衍生物，具有抗增殖活性。Zotarolimus 被专门开发作为局部输送支架用于预防冠状动脉再狭窄。 |
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Collingwood, R., Gibson, L., Sedlik, S., et al.Stent-based delivery of ABT-578 via a phosphorylcholine surface coating reduces neointimal formation in the porcine coronary modelCatheter Cardiovasc. Interv.65(2),227-232(2005)
Chen, Y.-W., Smith, M.L., Sheets, M., et al.Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppressionJ. Cardiovasc. Pharmacol.49(4),228-235(2007)
