WS6
Cat. No.：YN480807
CAS No. ：1421227-53-3
规格
价格(RMB)
库存
| 产品名称: | WS6 |
| CAS No.: | 1421227-53-3 |
| Chemical Name: | 4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide |
| Synonyms: | WS-6，WS 6 |
| 分子量: | 568.59 |
| 分子式: | C₂₉H₃₁F₃N₆O₃ |
| SMILES: | O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)CC3=CC=C(OC4=NC=NC(NC(C5CC5)=O)=C4)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WS6是促_beta_细胞增生的新型小分子，在啮齿类动物和人源原发性胰岛中EC50值为0.28uM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Shen, W., Tremblay, M.S., Deshmukh, V.A., et al.Small-molecule inducer of β cell proliferation identified by highthroughput screeningJ. Am. Chem. Soc.135(5),1669-1672(2013)
Corritore, E., Lee, Y.-S., Sokal, E.M., et al.β-cell replacement sources for type 1 diabetes: A focus on pancreatic ductal cellsTher. Adv. Endocrinol. Metab.7(4),182-199(2014)
Boerner, B.P., George, N.M., Mir, S.U.R., et al.WS6 induces both alpha and beta cell proliferation without affecting differentiation or viabilityEndocr. J.62(4),379-386(2015)
