Pseurotin A
Cat. No.：YN480855
CAS No. ：58523-30-1
规格
价格(RMB)
库存
| 产品名称: | Pseurotin A |
| CAS No.: | 58523-30-1 |
| Chemical Name: | (5S)-8S-benzoyl-2-[1S,2S-dihydroxy-3Z-hexen-1-yl]-9R-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione |
| Synonyms: | |
| 分子量: | 431.44 |
| 分子式: | C₂₂H₂₅NO₈ |
| SMILES: | O=C1C(C)=C([C@@H](O)[C@@H](O)/C=C\CC)O[C@]12C(N[C@@](OC)(C(C3=CC=CC=C3)=O)[C@@H]2O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pseurotin A，曲霉和其他真菌的次级代谢产物，是几丁质合成酶 (chitin synthase) 的竞争性抑制剂和神经发生剂。Pseurotin A 抑制 IgE 的产生 (IC50=3.6 μM)。Pseurotin A 具有抗肿瘤活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Maiya, S., Grundmann, A., Li, X., et al.Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatusChembiochem8(14),1736-1743(2007)
Vödisch, M., Scherlach, K., Winkler, R., et al.Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxiaJ. Proteome Res.10(5),2508-2524(2011)
Ishikawa, M., Ninomiya, T., Akabane, H., et al.Pseurotin A and its analogues as inhibitors of immunoglobulin E productionBioorg. Med. Chem. Lett.19(5),1457-1460(2009)
Komagata, D., Fujita, S., Yamashita, N., et al.Novel neuritogenic activities of pseurotin A and penicillic acidJ. Antibiot. (Tokyo)49(9),958-959(1996)
Hayashi, A., Fujioka, S., Nukina, M., et al.Fumiquinones A and B, nematicidal quinones produced by Aspergillus fumigatusBiosci. Biotechnol. Biochem.71(7),1697-1702(2007)
