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Apraclonidine hydrochloride

Cat. No.:YN480889

  • CAS No. :73218-79-8

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    • 产品名称: Apraclonidine hydrochloride
      CAS No.: 73218-79-8
      Chemical Name: 2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine, monohydrochloride
      Synonyms:ALO 2145
      分子量:281.57
      分子式:C₉H₁₁Cl₃N₄
      SMILES:NC1=CC(Cl)=C(NC2=NCCN2)C(Cl)=C1.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Apraclonidine hydrochloride (ALO 2145) 是一种选择性α2和弱 α1 受体激动剂,能有效降低人眼压。Apraclonidine hydrochloride 是一种局部滴眼液,有提升眼睑的能力。
      IC50和靶点:
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    • Rouot, B.R., and Snyder, S.H.[3H]Para-amino-clonidine: A novel ligand which binds with high affinity to alpha-adrenergic receptorsLife Sci.25(9),769-774(1979)

      Feller, D.J., and Bylund, D.B.Comparison of alpha-2 adrenergic receptors and their regulation in rodent and porcine speciesJ. Pharmacol. Exp. Ther.228(2),275-282(1984)

      Evans, R.G., and Haynes, J.M.Characterization of binding sites for [3H]-idazoxan, [3H]-P-aminoclonidine and [3H]-rauwolscine in the kidney of the dogClin. Exp. Pharmacol. Physiol.21(8),649-658(1994)

      Konno, F., Kusunoki, M., and Takayanagi, I.Receptor interactions of a series of imidazolines: Comparison of the alpha 2-adrenoceptors between the rabbit vas deferens and guinea pig ileumJpn. J. Pharmacol.44(2),171-178(1987)

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