TFMB-(R)-2-HG
Cat. No.：YN480973
CAS No. ：1445700-01-5
规格
价格(RMB)
库存
| 产品名称: | TFMB-(R)-2-HG |
| CAS No.: | 1445700-01-5 |
| Chemical Name: | (2R)-tetrahydro-5-oxo-2-furancarboxylic acid, [3-(trifluoromethyl)phenyl]methyl ester |
| Synonyms: | |
| 分子量: | 288.22 |
| 分子式: | C₁₃H₁₁F₃O₄ |
| SMILES: | O=C([C@@H](CC1)OC1=O)OCC2=CC=CC(C(F)(F)F)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TFMB-(R)-2-HG 是具有细胞膜渗透性的 (R)-2-HG，急性髓细胞性白血病 (AML) 的致癌因子。TFMB-(R)-2-HG 响应雌激素戒断损害SCF ER-Hoxb8 细胞分化。 |
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Losman, J.A., Looper, R.E., and Koivunen, P.(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversibleScience339(6127),1621-1625(2013)
Yang, H., Ye, D., Guan, K.L., et al.IDH1 and IDH2 mutations in tumorigenesis: Mechanistic insights and clinical perspectivesClin. Cancer Res.18(20),5562-5571(2012)
Xu, W., Yang, H., Liu, Y., et al.Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenasesCancer Cell19(1),17-30(2011)
Chowdhury, R., Yeoh, K.K., Tian, Y.M., et al.The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylasesEMBO Rep.12(5),463-469(2011)
