GLPG0974
Cat. No.：YN480979
CAS No. ：1391076-61-1
规格
价格(RMB)
库存
| 产品名称: | GLPG0974 |
| CAS No.: | 1391076-61-1 |
| Chemical Name: | 4-[[[(2R)-1-(benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]-butanoic acid |
| Synonyms: | GLPG-0974 |
| 分子量: | 485.00 |
| 分子式: | C₂₅H₂₅ClN₂O₄S |
| SMILES: | O=C(O)CCCN(C([C@]1(C)N(C(C2=CSC3=CC=CC=C32)=O)CC1)=O)CC4=CC=CC(Cl)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GLPG0974是游离脂肪酸受体-2 (free fatty acid receptor-2 (FFA2/GPR43)) 拮抗剂，IC50值为 9 nM。 |
| IC50和靶点: | |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Pizzonero, M., Dupont, S., Babel, M., et al.Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: From hit to clinicJ. Med. Chem.57(23),10044-10057(2014)
Bolognini, D., Barki, N., Butcher, A.J., et al.Chemogenetics defines receptor-mediated functions of short chain free fatty acidsNat. Chem. Biol.15(5),489-498(2019)
