Gefitinib impurity 1
Cat. No.:YN481057
产品名称: | Gefitinib impurity 1 |
CAS No.: | 675126-26-8 |
Chemical Name: | 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile; 2-Nitro-4-methoxy-5-[3-(morpholin-4-yl)]propoxybenzonitrile; 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile |
Synonyms: | |
分子量: | 321.33 |
分子式: | C₁₅H₁₉N₃O₅ |
SMILES: | N#CC1=CC(OCCCN2CCOCC2)=C(OC)C=C1[N+]([O-])=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Gefitinib impurity 1 是 Gefitinib 的杂质。Gefitinib 是一种有效的,具有口服活性的选择性EGFR酪氨酸激酶抑制剂,IC50为 33 nM。Gefitinib 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50为 54 nM),并阻断 EGF 刺激的肿瘤细胞中EGFR自磷酸化。Gefitinib 还可诱导细胞自噬 (autophagy)。Gefitinib 具有抗肿瘤活性。 |
IC50和靶点: | |
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Solvent & Solubility: |
Wang, J., et al.: Bioorganic Med. Chem. Lett. 16, 15, 4102-06, (2006)