Gefitinib impurity 5
Cat. No.:YN481173
产品名称: | Gefitinib impurity 5 |
CAS No.: | 199327-61-2 |
Chemical Name: | 7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(3H)-quinazolinone; 7-Methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one; |
Synonyms: | |
分子量: | 319.36 |
分子式: | C₁₆H₂₁N₃O₄ |
SMILES: | O=C1NC=NC2=C1C=C(OCCCN3CCOCC3)C(OC)=C2 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Gefitinib impurity 5 是 Gefitinib 的杂质。Gefitinib 是一种有效的,具有口服活性的选择性EGFR酪氨酸激酶抑制剂,IC50为 33 nM。Gefitinib 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50为 54 nM),并阻断 EGF 刺激的肿瘤细胞中EGFR自磷酸化。Gefitinib 还可诱导细胞自噬 (autophagy)。Gefitinib 具有抗肿瘤活性。 |
IC50和靶点: | |
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In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Kelly, L., et al.: Cancer Cell., 1, 421 (2002), Pandey, A., et al.: J. Med. Chem., 45, 3772 (2002),