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Risperidone E-oxime

Cat. No.:YN481191

  • CAS No. :691007-09-7

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    • 产品名称: Risperidone E-oxime
      CAS No.: 691007-09-7
      Chemical Name: 3-[2-[4-[(E)-(2,4-difluorophenyl)(hydroxyimino)methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
      Synonyms:
      分子量:430.49
      分子式:C₂₃H₂₈F₂N₄O₂
      SMILES:O=C1C(CCN2CCC(/C(C3=CC=C(F)C=C3F)=N\O)CC2)=C(C)N=C4N1CCCC4
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Risperidone E-oxime 是 Risperidone 的杂质。Risperidone 是 5-HT2 受体的阻断剂,P-糖蛋白 (P-Glycoprotein) 的抑制剂 和 dopamine D2 受体的拮抗剂,其对 5-HT2A 和 dopamine D2 受体的 Ki值分别为 4.8,5.9 nM。
      IC50和靶点:
      In Vitro:
      In Vivo:
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      Solvent & Solubility:
    • Bharathi, C., Chary, D.K., Kumar, M.S., et al.Identification, isolation and characterization of potential degradation product in risperidone tabletsJ. Pharm. Biomed. Anal.46(1),165-169(2008)

      Nejedly, T., Pilarova, P., Kastner, P., et al.Development and validation of rapid UHPLC method for determination of risperidone and its impurities in bulk powder and tabletsInt. J. Res. Pharm. Chem.4(2),261-266(2014)

      Colpaert, F.C.Discovering risperidone: The LSD model of psychopathologyNat. Rev. Drug Discov.2,315-320(2003)

      Rainer, M.K.Risperidone long-acting injection: A review of its long term safety and efficacyNeuropsychiatr. Dis. Treat.4(5),919-927(2008)

      Edwards, J.G.Risperidone for schizophreniaBMJ308(6940),1311-1312(1994)

      Bymaster, F.P., Calligaro, D.O., Falcone, J.F., et al.Radioreceptor binding profile of the atypical antipsychotic olanzapineNeuropsychopharmacology14(2),87-96(1996)

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