Risperidone E-oxime
Cat. No.:YN481191
产品名称: | Risperidone E-oxime |
CAS No.: | 691007-09-7 |
Chemical Name: | 3-[2-[4-[(E)-(2,4-difluorophenyl)(hydroxyimino)methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one |
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分子量: | 430.49 |
分子式: | C₂₃H₂₈F₂N₄O₂ |
SMILES: | O=C1C(CCN2CCC(/C(C3=CC=C(F)C=C3F)=N\O)CC2)=C(C)N=C4N1CCCC4 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Risperidone E-oxime 是 Risperidone 的杂质。Risperidone 是 5-HT2 受体的阻断剂,P-糖蛋白 (P-Glycoprotein) 的抑制剂 和 dopamine D2 受体的拮抗剂,其对 5-HT2A 和 dopamine D2 受体的 Ki值分别为 4.8,5.9 nM。 |
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Bharathi, C., Chary, D.K., Kumar, M.S., et al.Identification, isolation and characterization of potential degradation product in risperidone tabletsJ. Pharm. Biomed. Anal.46(1),165-169(2008)
Nejedly, T., Pilarova, P., Kastner, P., et al.Development and validation of rapid UHPLC method for determination of risperidone and its impurities in bulk powder and tabletsInt. J. Res. Pharm. Chem.4(2),261-266(2014)
Colpaert, F.C.Discovering risperidone: The LSD model of psychopathologyNat. Rev. Drug Discov.2,315-320(2003)
Rainer, M.K.Risperidone long-acting injection: A review of its long term safety and efficacyNeuropsychiatr. Dis. Treat.4(5),919-927(2008)
Edwards, J.G.Risperidone for schizophreniaBMJ308(6940),1311-1312(1994)
Bymaster, F.P., Calligaro, D.O., Falcone, J.F., et al.Radioreceptor binding profile of the atypical antipsychotic olanzapineNeuropsychopharmacology14(2),87-96(1996)