CP-91149
Cat. No.：YN481195
CAS No. ：186392-40-5
规格
价格(RMB)
库存
| 产品名称: | CP-91149 |
| CAS No.: | 186392-40-5 |
| Chemical Name: | 5-chloro-N-[(1S,2R)-3-(dimethylamino)-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide |
| Synonyms: | |
| 分子量: | 399.87 |
| 分子式: | C₂₁H₂₂ClN₃O₃ |
| SMILES: | O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N[C@@H](CC3=CC=CC=C3)[C@@H](O)C(N(C)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CP-91149 是GP (糖原磷酸化酶)的抑制剂。CP-91149 促进糖原的重新合成，但不导致糖原的过度积累。CP-91149 有用于2型糖尿病研究的潜能。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Martin, W.H., Hoover, D.J., Armento, S.J., et al.Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivoProc. Natl. Acad. Sci. USA95(4),1776-1781(1998)
Hoover, D.J., Lefkowitz-Snow, S., Burgess-Henry, J.L., et al.Indole-2-carboxamide inhibitors of human liver glycogen phosphorylaseJ. Med. Chem.41(16),2934-2938(1998)
Aiston, S., Hampson, L., Gómez-Foix, A.M., et al.Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: Evidence from metabolic control analysisJ. Biol. Chem.276(26),23858-23866(2001)
Schnier, J.B., Nishi, K., Monks, A., et al.Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expressionBiochem. Biophys. Res. Commun.309(1),126-134(2003)
