AVN-944
Cat. No.：YN481243
CAS No. ：297730-17-7
规格
价格(RMB)
库存
| 产品名称: | AVN-944 |
| CAS No.: | 297730-17-7 |
| Chemical Name: | N-[(1S)-1-[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]ethyl]-carbamic acid, (1R)-1-(cyanomethyl)propyl ester |
| Synonyms: | VX-944 |
| 分子量: | 477.51 |
| 分子式: | C₂₅H₂₇N₅O₅ |
| SMILES: | O=C(O[C@@H](CC#N)CC)N[C@H](C1=CC=CC(NC(NC2=CC=C(C3=CN=CO3)C(OC)=C2)=O)=C1)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AVN-944(VX-944)是选择性非竞争性IMPDH抑制剂，对IMPDH1和IMPDH2的Ki值为6-10nMIMPDH。 |
| IC50和靶点: | |
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Ishitsuka, K., Hideshima, T., Hamasaki, M., et al.Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathwayOncogene24(38),5888-5896(2005)
Floryk, D., and Thompson, T.C.Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cellsInt. J. Cancer123(10),2294-2302(2008)
