PX-12
Cat. No.：YN481352
CAS No. ：141400-58-0
规格
价格(RMB)
库存
| 产品名称: | PX-12 |
| CAS No.: | 141400-58-0 |
| Chemical Name: | 2-[(1-methylpropyl)dithio]-1H-imidazole |
| Synonyms: | IV-2 |
| 分子量: | 188.31 |
| 分子式: | C₇H₁₂N₂S₂ |
| SMILES: | CCC(SSC1=NC=CN1)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PX-12(IV-2)是可逆的硫氧还蛋白-1（Trx-1）抑制剂；抑制MCF-7 和HT-29 cells细胞生长的IC50值分别为1.9和2.9 μM。 |
| IC50和靶点: | |
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Welsh, S.J., Williams, R.R., Birmingham, A., et al.The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1α and vascular endothelial growth factor formationMol. Cancer Ther.2(3),235-243(2003)
Jin, X., Stamnaes, J., Klöck, C., et al.Activation of extracellular transglutaminase 2 by thioredoxinJ. Biol. Chem.286(43),37866-37873(2011)
Husbeck, B., and Powis, G.The redox protein thioredoxin-1 regulates the constitutive and inducible expression of the estrogen metabolizing cytochromes P450 1B1 and 1A1 in MCF-7 human breast cancer cellsCarcinogenesis23(10),1625-1630(2002)
