Tirapazamine
Cat. No.：YN481368
CAS No. ：27314-97-2
规格
价格(RMB)
库存
| 产品名称: | Tirapazamine |
| CAS No.: | 27314-97-2 |
| Chemical Name: | 1,2,4-benzotriazin-3-amine 1,4-dioxide |
| Synonyms: | 替拉扎明; SR259075; SR4233; Win59075 |
| 分子量: | 178.15 |
| 分子式: | C₇H₆N₄O₂ |
| SMILES: | NC1=[N+]([O-])C2=CC=CC=C2[N+]([O-])=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tirapazamine是一种抗癌剂，对实体瘤中的缺氧细胞具有选择性细胞毒性，从而诱导DNA中的单链和双链断裂，碱基损伤和细胞死亡。 |
| IC50和靶点: | |
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Brown, J.M.SR 4233 (tirapazamine): A new anticancer drug exploiting hypoxia in solid tumoursBr. J. Cancer.67(6),1163-1170(1993)
Reddy, S.B., and Williamson, S.K.Tirapazamine: A novel agent targeting hypoxic tumor cellsExpert. Opin. Investig. Drugs18(1),77-87(2009)
Moriwaki, T., Okamoto, S., Sasanuma, H., et al.Cytotoxicity of tirapazamine (3-amino-1,2,4-benzotriazine-1,4-dioxide)-induced DNA damage in chicken DT40 cellsChem. Res. Toxicol.30(2),699-704(2017)
Dorie, M.J., and Brown, J.M.Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatinCancer Res.53(19),4633-4636(1993)
El-Said, A., Menke, D., Dorie, M.J., et al.Comparison of the effectiveness of tirapazamine and carbogen with nicotinamide in enhancing the response of a human tumor xenograft to fractionated irradiationRadiat. Oncol. Investig.7(3),163-169(1999)
