PKR-IN-C16
Cat. No.：YN481377
CAS No. ：608512-97-6
规格
价格(RMB)
库存
| 产品名称: | PKR-IN-C16 |
| CAS No.: | 608512-97-6 |
| Chemical Name: | 6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one |
| Synonyms: | imoxin, C16, Imidazolo-oxindole PKR inhibitor C16 |
| 分子量: | 268.29 |
| 分子式: | C₁₃H₈N₄OS |
| SMILES: | O=C1/C(C2=C(SC=N3)C3=CC=C2N1)=C\C4=CN=CN4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PKR-IN-C16 是特异性蛋白激酶 (PKR) 抑制剂。PKR-IN-C16 能够抑制 PKR 的自磷酸化，PKR 在原代神经元细胞培养中诱导的翻译阻断可被 PKR-IN-C16 解除。 |
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Couturier, J., Morel, M., Pontcharraud, R., et al.Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid β (Aβ)-treated cells and in APPSLPS1 knock-in miceJ. Biol. Chem.285(2),1272-1282(2010)
Zhu, P.J., Huang, W., Kalikulov, D., et al.Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibitionCell147(6),1384-1396(2011)
Jammi, N.V., Whitby, L.R., and Beal, P.A.Small molecule inhibitors of the RNA-dependent protein kinaseBiochem. Biophys. Res. Commun.308(1),50-57(2003)
Shimazawa, M., and Hara, H.Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stressNeurosci. Lett.409(3),192-195(2006)
Ingrand, S., Barrier, L., Lafay-Chebassier, C., et al.The oxindole/imidazole derivative C16 reduces in vivo brain PKR activationFEBS Lett.581(23),4473-4478(2007)
