SR8278
Cat. No.：YN481390
CAS No. ：1254944-66-5
规格
价格(RMB)
库存
| 产品名称: | SR8278 |
| CAS No.: | 1254944-66-5 |
| Chemical Name: | 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid, ethyl ester |
| Synonyms: | SR8278,SR-8278，SR 8278 |
| 分子量: | 361.48 |
| 分子式: | C₁₈H₁₉NO₃S₂ |
| SMILES: | CSC1=CC=C(C(N2C(C(OCC)=O)CC(C=CC=C3)=C3C2)=O)S1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SR8278 是一种竞争性核血红素受体REV-ERB合成拮抗剂。SR8278 抑制 REV-ERBα 转录活性，EC50为 0.47 μM。SR8278 用于调节生物体内的代谢和研究生物节律。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Duez, H., and Staels, B.Rev-erb-α: An integrator of circadian rhythms and metabolismJ. Appl. Physiol. (1985)107(6),1972-1980(2009)
Kojetin, D., Wang, Y., Kameneck, T.M., et al.Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERBACS Chem. Biol.6(2),131-134(2011)
Vieira, E., Marroquí, L., Figueroa, A.L., et al.Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cellsPLoS One8(7),1-15(2013)
