Irosustat
Cat. No.：YN481396
CAS No. ：288628-05-7
规格
价格(RMB)
库存
| 产品名称: | Irosustat |
| CAS No.: | 288628-05-7 |
| Chemical Name: | sulfamic acid, 6,7,8,9,10,11-hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl ester |
| Synonyms: | STX64; BN83495; 667-Coumate |
| 分子量: | 309.34 |
| 分子式: | C₁₄H₁₅NO₅S |
| SMILES: | O=C1OC2=CC(OS(=O)(N)=O)=CC=C2C3=C1CCCCC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Irosustat 是一种有效的类固醇硫酸酯酶 (steroid sulfatase) 抑制剂，IC50值为 8 nM，具有抗乳腺癌的活性。 |
| IC50和靶点: | |
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Malini, B., Purohit, A., Ganeshapillai, D., et al.Inhibition of steroid sulphatase activity by tricyclic coumarin sulphamatesJ. Steroid Biochem. Mol. Biol.75(4-5),253-258(2000)
Ho, Y.T., Purohit, A., Vicker, N., et al.Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamatesBiochem. Biophys. Res. Commun.305(4),909-914(2003)
Jang, H.-L., El-Gamal, M.I., Choi, H.-E., et al.Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophagesBioorg. Med. Chem. Lett.24(2),571-575(2014)
Purohit, A., Woo, L.W., Potter, B.V., et al.In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATECancer Res.60(13),3394-3396(2000)
