Tafamidis
Cat. No.：YN481403
CAS No. ：594839-88-0
规格
价格(RMB)
库存
| 产品名称: | Tafamidis |
| CAS No.: | 594839-88-0 |
| Chemical Name: | 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylic acid |
| Synonyms: | 氯苯唑酸 |
| 分子量: | 308.12 |
| 分子式: | C₁₄H₇Cl₂NO₃ |
| SMILES: | O=C(C1=CC=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tafamidis 是一种有效、选择性的transthyretin (TTR)稳定剂，对野生型 WT-TTR 和突变型同源四聚体 V30M-TTR，V122I-TTR 的活性相当，EC50值为 2.7-3.2 μM。Tafamidis 抑制淀粉样蛋白的生成。 |
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Bulawa, C.E., Connelly, S., Devit, M., et al.Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascadeProc. Natl. Acad. Sci. USA109(24),9629-9634(2012)
Scott, L.J.Tafamidis: A review of its use in familial amyloid polyneuropathyDrugs74(12),1371-1378(2014)
