Uridine triacetate
Cat. No.：YN481411
CAS No. ：4105-38-8
规格
价格(RMB)
库存
| 产品名称: | Uridine triacetate |
| CAS No.: | 4105-38-8 |
| Chemical Name: | 2',3',5'-triacetate uridine |
| Synonyms: | Tri-O-acetyl uridine |
| 分子量: | 370.31 |
| 分子式: | C₁₅H₁₈N₂O₉ |
| SMILES: | O=C(NC(C=C1)=O)N1[C@H](O2)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2COC(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Uridine triacetate (Tri-O-acetyl uridine) 是尿苷的口服前药。Uridine triacetate 脂溶性强，在肠道内迅速吸收，在循环中迅速脱乙酰，生成游离尿苷。Uridine triacetate 用于研究危及生命的 5-氟尿嘧啶和卡培他滨的毒性。Uridine triacetate 提供高浓度尿苷，竞争与有毒 5-FU 代谢物。 |
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Ashour, O.M., Naguib, F.N.M., and el Kouni, M.H.5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2',3',5'-tri-O-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration: Implications for chemotherapyBiochem. Pharmacol.51(12),1601-1611(1996)
Saydoff, J.A., Garcia, R.A.G., Browne, S.E., et al.Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's diseaseNeurobiol. Dis.24(3),455-465(2006)
von Borstel, R.W., O'Neil, J.D., Saydoff, J.A., et al.Uridine triacetate for lethal 5-FU toxicity due to dihydropyrimidine dehydrogenase (DPD) deficiencyJ. Clin. Oncol.28(15_supp),e13505-e13505(2010)
