Migalastat hydrochloride
Cat. No.：YN481413
CAS No. ：75172-81-5
规格
价格(RMB)
库存
| 产品名称: | Migalastat hydrochloride |
| CAS No.: | 75172-81-5 |
| Chemical Name: | (2R,3S,4R,5S)-2-(hydroxymethyl)-3,4,5-piperidinetriol, monohydrochloride |
| Synonyms: | GR181413A |
| 分子量: | 199.63 |
| 分子式: | C₆H₁₄ClNO₄ |
| SMILES: | O[C@H]1[C@@H](CO)NC[C@H](O)[C@H]1O.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Migalastat hydrochloride (GR181413A) 是一种有效和竞争性的α-galactosidase A抑制剂，对人α-Gal A的IC50值为0.04 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Asano, N., Ishii, S., Kizu, H., et al.In vitro inhibition and intracellular enhancement of lysosomal α-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivativesEur. J. Biochem.267(13),4179-4186(2000)
Ishii, S., Chang, H.H., Yoshioka, H., et al.Preclinical efficacy and safety of 1-deoxygalactonojirimycin in mice for Fabry diseaseJ. Pharmacol. Exp. Ther.328(3),723-731(2009)
Siekierska, A., De Baets, G., Ruemers, J., et al.α-Galactosidase aggregation is a determinant of pharmacological chaperone efficacy on Fabry disease mutantsJ. Biol. Chem.287(34),28386-28397(2012)
