Teriflunomide
Cat. No.：YN481430
CAS No. ：163451-81-8
规格
价格(RMB)
库存
| 产品名称: | Teriflunomide |
| CAS No.: | 163451-81-8 |
| Chemical Name: | 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2Z-butenamide |
| Synonyms: | 特立氟胺; A77 1726 |
| 分子量: | 270.21 |
| 分子式: | C₁₂H₉F₃N₂O₂ |
| SMILES: | C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O.[(Z)] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Teriflunomide (A77 1726) 是来氟米特的活性代谢产物，可用于类风湿性关节炎的研究。 它抑制嘧啶合成，因此有效降低T细胞和B细胞增殖。 |
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Papageorgiou, C., Zurini, M., Weber, H.-P., et al.Leflunomide's bioactive metabolite has the minimal structural requirements for the efficient inhibition of human dihydroorotate dehydrogenaseBioorg. Chem.25(4),233-238(1997)
Burger, D., Begué-Pastor, N., Benavent, S., et al.The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E2, matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytesRheumatology (Oxford)42(1),89-96(2003)
Li, L., Liu, J., Delohery, T., et al.The effects of teriflunomide on lymphocyte subpopulations in human peripheral blood mononuclear cells in vitroJ. Neuroimmunol.265(1-2),82-90(2013)
Merrill, J.E., Hanak, S., Pu, S.-F., et al.Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitisJ. Neurol.256(1),89-103(2009)
