UPF-648
Cat. No.：YN481444
CAS No. ：213400-34-1
规格
价格(RMB)
库存
| 产品名称: | UPF-648 |
| CAS No.: | 213400-34-1 |
| Chemical Name: | (1S,2S)-2-(3,4-dichlorobenzoyl)-cyclopropanecarboxylic acid |
| Synonyms: | |
| 分子量: | 259.09 |
| 分子式: | C₁₁H₈Cl₂O₃ |
| SMILES: | O=C([C@@H]1[C@@H](C(C2=CC=C(Cl)C(Cl)=C2)=O)C1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UPF-648是犬尿氨酸3-单加氧酶(KMO)有效抑制剂，1uM浓度下能达到约81%的抑制效果，对犬尿素转氨酶KAT无抑制作用。 |
| IC50和靶点: | |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Pellicciari, R., Amori, L., Costantino, G., et al.Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylaseAdv. Exp. Med. Biol.527,621-628(2003)
Ceresoli-Borroni, G., Guidetti, P., Amori, L., et al.Perinatal kynurenine 3-hydroxylase inhibition in rodents: Pathophysiological implicationsJ. Neurosci. Res.85(4),845-854(2007)
Campesan, S., Green, E.W., Breda, C., et al.The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's diseaseCurr. Biol.21(11),9611-9966(2011)
Rojewska, E., Ciapała, K., Piotrowska, A., et al.Pharmacological inhibition of indoleamine 2,3-dioxygenase-2 and kynurenine 3-monooxygenase, enzymes of the kynurenine pathway, significantly diminishes neuropathic pain in a rat modelFront. Pharmacol.9,724(2018)
