SR 11302
Cat. No.：YN481474
CAS No. ：160162-42-5
规格
价格(RMB)
库存
| 产品名称: | SR 11302 |
| CAS No.: | 160162-42-5 |
| Chemical Name: | (2E,4E,6Z,8E)-3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid |
| Synonyms: | |
| 分子量: | 376.53 |
| 分子式: | C₂₆H₃₂O₂ |
| SMILES: | O=C(O)/C=C(C)/C=C/C=C(C1=CC=C(C)C=C1)/C=C/C2=C(C)CCCC2(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SR 11302 是激活蛋白-1 (AP-1) 转录因子抑制剂。SR 11302 是一种类视黄醇，可特异性抑制 AP-1 活性，而不会激活视黄酸反应元件 (RARE) 的转录。 |
| IC50和靶点: | |
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Huang, C., Ma, W.Y., Dawson, M.I., et al.Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acidProc. Natl. Acad. Sci. USA94(11),5826-5830(1997)
Shiohara, M., Dawson, M.I., Hobbs, P.D., et al.Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitroBlood93(6),2057-2066(1999)
Kankaanranta, H., Ilmarinen, P., Zhang, X., et al.Tumour necrosis factor-α regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-κB and AP-1PLoS One9(2),e90298(2014)
