ATN-224
Cat. No.：YN481529
CAS No. ：649749-10-0
规格
价格(RMB)
库存
| 产品名称: | ATN-224 |
| CAS No.: | 649749-10-0 |
| Chemical Name: | 2-hydroxy-N,N,N-trimethyl-ethanaminium, tetrathioxomolybdate |
| Synonyms: | Bis(choline)tetrathiomolybdate |
| 分子量: | 432.56 |
| 分子式: | C₁₀H₂₈MoN₂O₂S₄ |
| SMILES: | OCC[N+](C)(C)C.OCC[N+](C)(C)C.[S-][Mo]([S-])(=S)=S |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ATN-224 是一种Cu2+/Zn2+-超氧化物歧化酶 1 (SOD1) 抑制剂。ATN-224 作用内皮细胞，抑制抑制SOD1活性，IC50为 17.5±3.7 nM。 |
| IC50和靶点: | |
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Doñate, F., Juarez, J.C., Burnett, M.E., et al.Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)Br. J. Cancer98(4),776-783(2008)
Lee, K., Briehl, M.M., Mazar, A.P., et al.The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignanciesFree Radic. Biol. Med.60,157-167(2013)
Lee, K., Hart, M.R., Briehl, M.M., et al.The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphomaInt. J. Oncol.45(1),439-447(2014)
Yoo, J.Y., Yu, J.G., Kaka, A., et al.ATN-224 enhances antitumor efficacy of oncolytic herpes virus against both local and metastatic head and neck squamous cell carcinomaMol. Ther. Oncolytics2,15008(2015)
